The Amphisbaena IV (天使炎上篇IV Tenshi Enjō Hen Yon) is the twelfth episode of the Strike the Blood anime.
When Kojou is disabled in the battle with Kanon, Yukina retreats with him behind La Folia's barrier. Both Yukina and La Folia share their blood with Kojou to aid in his recovery and the awakening of a new power. They have no choice but to rush to Kanon's rescue as her ego slips beyond control and she loses her grip on her humanity.
- Kojou vs Kanon. (started and concluded)
- La Folia vs Lowe. (started and concluded)
- Yukina vs Beatrice.(started and concluded)
- 3rd Familiar - Gemini Tritos - Al Meissa Mercury.