Return of the Alchemist II (錬金術師の帰還篇II Renkinjutsushi no Kikan Hen Ni) is the twenty-first episode of the Strike the Blood anime.
Asagi has been caught up in Kou's attack. Kojou and Yukina rush to save her, deciding to take her to Mimori's lab for treatment... but when they stop at Kojou's place on the way, another personality takes over Asagi's body.
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- Nina possesses Asagi and helps her.
- Ninas meet Kojou.
- Natsuki takes immortal body core from Kou.
- Wiseman appears in his liquid form.
- Yukina, Nagisa, Kanon and class embarks on a Nautical Journey.